Journal of Drug Designing-Lupine Publishers

Solid State Characterization for a Comparative Evaluationof the Biofield Energy Treated and Un-treatedAscorbic Acid by Snehasis Jana in DDIPIJ in Lupine Publishers.

Ascorbic acid is a water-soluble vitamin that mainly acts as an antioxidant and helps in controlling and maintaining various body functions. The study was designed to analyze the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of ascorbic acid by using sophisticated analytical techniques. For the study, the test sample ascorbic acid was divided into the control and treated sample. To the control sample, no Biofield Energy Treatment was provided. However, the treated sample received the Biofield Energy Treatment remotely by the renowned Biofield Energy Healer, Alice Branton, USA. The PXRD peak intensities and crystallite sizes of the treated sample significantly altered ranging from -78.43% to 1168.06% and -62.38% to 126.83%, respectively; along with 24.99% decrease in the average crystallite size as compared to the control sample. The particle size values in the treated sample by 9.59% (d10), 21.63% (d50), 16.55% (d90), and 17.97% {D(4,3)}, respectively; hence the specific surface area was increased by 16.67% compared to the control sample. The weight loss was increased by 6.67%; however, the residue amount was found to be significantly decreased by 28.59% in the treated sample compared to the control sample. The Tmax of the treated sample corresponding to 1st and 2nd peaks were decreased by 0.33% and 4.09%, respectively as compared to the control sample. Moreover, the latent heat of fusion was significantly increased by 13.74% as compared to the control sample. Besides, the degradation temperature and ΔHdecomposition of the treated sample were significantly reduced by 6.54% and 20.46%, respectively, as compared to the control sample. The Trivedi Effect® might help in forming a novel polymorphic form of ascorbic acid that may also prove to be more soluble, absorbable, and bioavailable than the untreated sample. Thus, the Trivedi Effect® might be considered as a novel approach for designing the more efficacious ascorbic acid containing nutraceutical/pharmaceutical formulations. To know more click on below link.

https://lupinepublishers.com/drug-designing-journal/fulltext/solid-state-characterization-for-a-comparative-evaluation.ID.000149.php

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Journal of Drug Design and Development-Lupine Publishers

Development of Some Eco-Efficient and SelectiveChemical Processes and Products Using Sustainableand Green Chemistry Approaches by Isak R Shaikh in DDIPIJ in Lupine Publishers.

Historical records show that scientific advancements accounted for substantial changes in our life-style and wellbeing. The Industrial Revolution took place in the western countries in the 1700s when people first appreciated the terms ‘science’ and ‘technology’ and valued the applications of ‘technological innovations’ for their commercialization. During the World Wars, people experienced use of science and technology for destructive purposes. The 20th century science revolutionized the living standard of mankind and offered solutions to great socio-economic or strategic challenges of the time. Though industrialization is considered as an essential feature of economic growth, it at times is infamous due to the adverse environmental health consequences caused by the release of pollutants. Policies are being placed to create a course of action, followed by enactment (of a law), and then rules & regulations that are designed to carry out that law successfully. Today, the environmental policymaking process in most of the developed nations relies heavily on the transition to sustainable production and consumption patterns. Public support is being generated through organized ways to educate all about the environmental issues and research. In the spirit of that, recent science has seen major advances in the ongoing endeavors directed towards diminishing the impact of anthropogenic and industrial activities on the environment.

https://lupinepublishers.com/drug-designing-journal/fulltext/development-of-some-eco-efficient-and-selective-chemical-processes-and-products.ID.000145.php

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Journal of Drug Design and Research-Lupine Publishers

Bioequivalent Drugs: Towards A Needed HolisticParadigm Shift? by François-Xavier Lacasse in DDIPIJ in Lupine Publishers.

The author of this short communication has been working in and teaching drug development for the last 20 years. He has been involved in more than 100 drug development projects, including drug delivery, medical device, biologics, innovators and generic drugs. He has also been involved in all the steps that are needed to file properly to different governmental agencies investigational new drug applications (IND), clinical trial applications (CTA), abbreviated and new drug applications/submissions (ANDA\S; NDA/S), 505b2, 510k and biologics legal applications (BLA). After several other interactions with all the other actors, such as Health Canada (HC), the Food and Drug Agency (FDA), the European Medicines Agency (EMA), pharmacovigilance companies and consultants, public relation companies, insurance companies and especially patients, the author has decided to gather all the comments in order to initiate a kind of a new debate on the innovators and generic drugs. However, the goal of this current expert opinion is not to generate conflicts, or to compare generic versus innovator drugs in the sense that one is better than the other. To know more click on below link.

https://lupinepublishers.com/drug-designing-journal/fulltext/bioequivalent-drugs-towards-a-needed-holistic-paradigm-shift.ID.000144.php

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Intellectual Property Journal-Lupine Publishers

Genotoxic Impurities and Its Risk Assessment in DrugCompounds by Tabrez Shaikh in DDIPIJ in Lupine Publishers.

Pharmaceutical drugs are always associated with some unwanted chemicals along with active components. This unwanted chemical compound is called an impurity. Thus, the common definition of impurity is any substance coexisting with the drug substance, such as starting material, reagents, catalyst, raw material or intermediates arising during the synthesis or develop during storage or shipment of the drug. Impurities provide no benefit to the patient while it may have the potential to cause the adverse effect. International Council for Harmonisation in its guideline ICH S2 (R1) defines genotoxicity as “a broad term that refers to any deleterious change in the genetic material, regardless of the mechanism by which the change is induced.” While genotoxic impurities have been defined as “Impurity that has been demonstrated to be genotoxic in an appropriate genotoxicity test model, e.g., bacterial gene mutation (Ames) test” . A potential genotoxic impurity (PGI) has been defined as an “Impurity that shows a Structural alert for genotoxicity but that has not been tested in an experimental test model. Here potentially relates to genotoxicity, not to the presence or absence of this impurity”. Genotoxic impurities impact the genetic material by means of mutations through chromosomal breaks, rearrangements, covalent binding or insertion into the DNA during replication. These changes in the genetic material, caused by the exposure to very low levels of a genotoxic chemical, can lead to cancer. Thus, it is very important to identify genotoxic impurities in drugs followed by monitoring and control at very low levels to ensure safety to the public. To know more click on below link.

https://lupinepublishers.com/drug-designing-journal/fulltext/genotoxic-impurities-and-its-risk-assessment-in-drug-compounds.ID.000143.php

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Journal of Drug Designing- Lupine Publishers

Science and War Through the Ages by Benjamín Ruiz Loyola in DDIPIJ in Lupine Publishers.

In all animal species competition between individuals is presented to obtain mainly food and reproduction; When there are not enough satisfiers, there are disputes that usually stop when there is a winner, without individuals dying. The defeated one retires, and the winner is satisfied with the victory and, eventually, with the dominion over the rest of the group, which implies that he will eat and mate before the others. So far, animals do not have too much trouble. But the human is a very special animal, because he has a memory.Remembering the past allows you to anticipate the future; the loser analyzes the reasons that made his opponent win and plans how to win in the next match. The winner does the same to strengthen their strengths, overcome the weak and anticipate the actions of the opponent, exactly as in a game of chess. It then presents the convenience of killing the loser, in order to avoid his rematch and let future challengers know what to expect. When it is evident that a combat between individuals anticipates a defeat, it is sought to go for reinforcements thus forming the first armies, often initiated by groups of losers who seek to defeat the former winner. And so, a chain is generated. In a short time, human beings begin to wage war not because the species is more violent, but because it is more intelligent. Precisely, knowledge is constructed from remembering, analyzing, anticipating and reproducing, in such a way that the human being builds his knowledge in charitable matters and in others that are rather negative.To know more click on below link.

https://lupinepublishers.com/drug-designing-journal/fulltext/science-and-war-through-the-ages.ID.000142.php

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Journal of Drug Design and Development-Lupine Publishers

Would Hydroxychloroquine Be A New PromisingDrug in Managing Antiphospholipid Syndrome?

by Amani Mohsen in DDIPIJ in Lupine Publishers.

Once Antiphospholipid syndrome (APS) is diagnosed, risk profile of the patient will impact its management whether there was a previous thrombotic event or not, association with other autoimmune disorders, presence of other obstetrical complications as well as being currently pregnant. The current recommended regimen for preventing obstetrical complications. The current recommended regimen for preventing obstetrical complications includes low molecular weight Heparin and low dose aspirin. This regimen decreases the risk of miscarriage by only 54%. Here, we will review the studies that evaluated adding Hydroxychloroquine (HCQ) to the treatment of APS and how effective it would be.To know more click on below link.

https://lupinepublishers.com/drug-designing-journal/fulltext/would-hydroxychloroquine-be-a-new-promising-drug-in-managing-antiphospholipid-syndrome.ID.000141.php

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Journal of Drug Design and Research-Lupine Publishers

FTIR Analysis & Dielectric Constant for Some IronBismuth Borate Glasses by Hossam Mohammed Gomaa  in DDIPIJ in Lupine Publishers.

Some of iron bismuth borate oxide glasses were prepared to form a series of glass samples contain a constant and a fixed amount of Fe₂O₃ whereas the B₂O₃ was replaced by Bi₂O₃, according to the formula 20 mol % Fe₂O₃–(15 + x) mol % Bi2O3–(65–x) mol % B₂O₃, where 0 ≤ x ≤ 20. The X-ray diffraction and FTIR Spectra showed formation of homogenous short-range order structures. The values of the refractive index were estimated using both FTIR date room temperature dialectic measurements are in a good agreement with each other. It is clear that the ε increased with the increasing of Bi₂O₃ content.

https://lupinepublishers.com/drug-designing-journal/fulltext/ftir-analysis-dielectric-constant-for-some-iron-bismuth-borate-glasses.ID.000139.php

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Journal of Drug Design and Research-Lupine Publishers

A Review on The Phytochemical and Pharmacological Properties Barringtonia Asiatica by Isaac John Umaru in DDIPIJ in Lupine Publishers.

A review of Barringtonia asiatica considered to be a mangrove associated species is made to update its Phytochemical and Pharmacological Properties which is claimed to be a broad-spectrum medicinal property. Barringtonia asiatica was commonly used in various country of the world for treatment of liver disorder, diarrheal disease, eye disease, as well as antifungal and antibacterial, as well as chest pains and heart troubles. It was also considered a fish killer; this has been identified as a source of Natural products with potentials as an antitumor. The aim of the present review is to provide detailed information regarding geographical distribution, phytochemicals and pharmacological properties of this plant.To know more click on below link.

https://lupinepublishers.com/drug-designing-journal/fulltext/a-review-on-the-phytochemical-and-pharmacological-properties-barringtonia-asiatica.ID.000138.php

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Drug Designing & Intellectual Properties journals-Lupine Publishers

Potential Molecular Docking of FourAcetylcholinesterase Inhibitors by Abdul M Gbaj in DDIPIJ in Lupine Publishers.

Molecular modeling attempts to study the function, structure and inhibition of the acetylcholinesterase enzyme due to the fact that the inhibition of this enzyme is importance to medical conditions such as Alzheimer’s disease, myasthenia gravis and Parkinson’s disease, and it is also important in eminent toxicological susceptibility to nerve agents. In this study we present an approach for forecasting the inhibitory activity of acetylcholinesterase (AChE) inhibitors by using docking studies. The docking studies were done on acetylcholinesterase to attain the conformation of the enzyme in water surroundings. The obtained conformation of the enzyme was used for docking with four inhibitors (physostigmine, neostigmine, pyridostigmine and rivastigmine). Docking analysis showed that hydrogen bonds and hydrophobic interactions play important tasks in the acetylcholinesterase -inhibitor complex. Subsequently, all inhibitors that bind at the catalytic site of acetylcholinesterase and their interactions with acetylcholinesterase were studied. In addition, conformation stability of acetylcholinesterase -inhibitors was studied using simulation docking technique. The complex showed that acetylcholinesterase conformation did not change significantly in the presence of the four inhibitors. This paper showed important studies on acetylcholinesterase and assists to illuminate the four inhibitors interdependencies using molecular modeling.

https://lupinepublishers.com/drug-designing-journal/fulltext/potential-molecular-docking-of-four-acetylcholinesterase-inhibitors.ID.000136.php

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Journal of Drug Design and Development-Lupine Publishers

Ionic Liquid Technology: A Budding InnovativePodium for the Pharmaceutical Industry by Kapoor D in DDIPIJ in Lupine Publishers.

Ionic liquids considered to be a reasonably current magical chemical due their unique properties, have a large variety of applications in all areas of the chemical and pharmaceutical industries. The areas of application consist electrolyte in batteries, lubricants, plasticizers, solvents and catalysis in synthesis, matrices for mass spectroscopy, solvents to manufacture nano-materials, extraction, gas absorption agents, etc. Non-volatility and nonflammability are their widespread characteristics giving them a beneficial edge in a variety of applications. Ionic liquids can be considered as green solvents due to their very low vapor pressure and wide range of applications with unique physical and chemical properties. Ionic liquids use for clean and efficient energy, through the development of a broad swath of energy technologies, such as advanced batteries, dye-sensitized solar cells, double layer capacitors, actuators, fuel cells, thermo-cells, and water splitting, essentially related to highly efficient carbon capture and storage technologies and resource efficiency to date.

https://lupinepublishers.com/drug-designing-journal/fulltext/ionic-liquid-technology-a-budding-innovative-podium-for-the-pharmaceutical-industry.ID.000135.php

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Lupine Publishers-Journal of Intellectual Properties

Current Challenges and Obstacles to DrugDevelopment for Chagas Disease by Cauê Benito Scarim in DDIPIJ in Lupine Publishers.

Chagas disease is a protozoan infection which was first identified more than one hundred years ago. But even now, drugs to treat the latent and chronic phases of the disease are not available. The success of a drug design is highly dependent on activity and toxicity. In the case of Chagas disease, questions remain as to identifying the best treatment (mainly for the chronic phase), and how new drugs and drug combinations compare to current therapy. The principal priority of this mini-review is to report the enormous difficulty that pharmaceutical chemists encounter in the development of new drugs for neglected tropical infectious diseases, in this case Chagas disease.

https://lupinepublishers.com/drug-designing-journal/fulltext/current-challenges-and-obstacles-to-drug-development-for-chagas-disease.ID.000134.php

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Lupine Publishers: Lupine Publishes : Open Access Publisher

Lupine Publishers: Lupine Publishes : Open Access Publisher: Lupine Publishers Lupine Publishers    is a world’s leading Online Publishing repository, a  genuine publisher  with quality  medical jo...

Intellectual Property Journal- Lupine Publishers

Successively Substituting an Additional 4-(2-Aminoethyl) Aniline Group in Fabricated Isoindoline-1,3-Dione Scaffold Enhances the Antimicrobial Potency: Part II of Research by Debarshi Kar Mahapatra in DDIPIJ in Lupine Publishers

The irrational use of antimicrobial agents for several decades has led to the drug-resistance among the patient population. Overcoming the present drug-resistance is a major challenge for modern day scientists. In order to counter this problem, several approaches have been utilized, one of which involve drug design and discovery, where new classes or unexplored chemical moieties are explored for a particular activity, either serendipitously or quite rationally. Learning lessons from the previously synthesized four compounds (Part-I of Research), we have now (Part-II of Research) designed two compounds (3 and 5) by incorporating an additional 4-(2-aminoethyl)aniline group in the fabricated isoindoline-1,3-dione scaffold by successive synthetic step utilizing similar protocol and screened them against the above four mentioned pathogenic microbes in a similar way. The present exploration is an attempt to rationally overcome the microbial drug resistance by the efficacious and potent nature of the compounds. Compound (5) exhibited the highest activity against A. niger with ZOI diameter of >29mm. All the compounds showed more or less nearly the same activity. From this study, it may be concluded that substituting the amine/amide-based components leads to an increase in the potency of the compared along with better-anti-fungal activity. Therefore, the current exploration helped to design the compounds which have better potency than our previous reports and also providing imperative knowledge regarding the selection of the substituents. The encouraging results will further motivate us in developing novel and better inhibitors of phthalimide scaffold in the future.

https://lupinepublishers.com/drug-designing-journal/abstracts/successively-substituting-an-additional-4-2-aminoethyl-aniline-group-in-fabricated.ID.000132.php
https://lupinepublishers.com/drug-designing-journal/fulltext/successively-substituting-an-additional-4-2-aminoethyl-aniline-group-in-fabricated.ID.000132.php

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journal of Drug Designing- Lupine Publishers

Cytotoxicity and Antioxidant Potentials of Barringtonia Asiatica Essential Oil by Isaac John Umaru in DDIPIJ in Lupine Publishers

Essential oils are liquid mixture of volatile compound obtained from aromatic plants. It was observed that many essential oils have antioxidant properties and can present antimicrobial activities. The Aim of the present study were:
a) to determine the cytotoxicity lethality of the leafs and stem-bark of Barringtonia asiatica using brine shrimp (Artimia salina).

b) to evaluate the antioxidant potential of composition of the leaf and stem-bark essential oil using the DPPH (2,2-diphenyl-1- picrylhydrazyl) free radical scavenging assay. The essential oil exhibited a mild toxicity and significant IC50 of 36.55μg/mL and 22.10μg/mL value of antioxidant potential leaf and stem-bark of Barringtonia asiatica respectively.

https://lupinepublishers.com/drug-designing-journal/abstracts/cytotoxicity-and-antioxidant-potentials-of-barringtonia-asiatica-essential-oil.ID.000131.php
https://lupinepublishers.com/drug-designing-journal/fulltext/cytotoxicity-and-antioxidant-potentials-of-barringtonia-asiatica-essential-oil.ID.000131.php

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Drug Designing & Intellectual Properties journals- Lupine Publishers

Beyond Pain, Fear, Withdrawal-Findings, And Problems Involving Change - Treatment and Application for A Chronic Addiction on Alcohol Do Not End by Loai Aljerf in DDIPIJ in Lupine Publishers

Alcohol use disorders (AUD) involving hazardous, harmful and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of the common inhibitors in the treatment of patients with AUD, taking into consideration, the short- and long- terms abstinence. An extensive literature search conducted in MEDLINE, PubMed, Scopus and CINAHL databases identified 776 articles, which were then evaluated for pre‐specified criteria for relevance and quality assurance. A total of 38 articles, including 36 human studies and 2 animal studies, were selected for this review. Many inhibitors used in the treatment of alcoholism and some were considered of effective medication when their intakes are supervised by an expert. However, their therapeutic efficacies vary widely; for instance, disulfiram is a pro-drug that requires its transformation into an active form and because it shows a wide range of secondary effects, it often prevents the use of doses that ensure full therapeutic effectiveness. Sex hormones play an important role in establishing sex‐distinctive brain structural and functional variations that could contribute to the sex differences in alcohol consumption behavior. Existing evidence supports the association of increased testosterone level and increased risk for alcohol use and AUD in males. In contrast, the evidence supports the association of increased estrogen level and increased alcohol use in females. Much less is known about the impact of progestins on alcohol use and misuse in human subjects. Future observational and experimental studies conducted in both sexes with a comprehensive hormone panel are needed to elucidate the impact of the interplay between various sex hormone levels during various developmental stages on alcohol userelated phenotypes and AUD. On the other hand, alcohol withdrawal-especially delirium tremens (DT)-is a potentially life-threatening condition. While short-term treatment regimens and factors that predispose to more severe symptomatology have been extensively studied, little attention has been paid to the clinical epidemiology and long-term care of the chronic medical, addictive, psychiatric, and psychosocial problems faced by these patients. Chronic alcoholic patients are frequently suffering from specific micronutrient deficiencies, including vitamins involved in one carbon metabolism. The deficiencies commonly involve folate, vitamin B6, thiamine, and vitamin A. Inadequate dietary intake is a major cause of the vitamin deficiency. As a consequence of chronic alcohol intake, could lead to metabolic disruption and potentially to hyperhomocysteinemia. Alcoholism can affect the absorption, storage, metabolism, and activation of many of these vitamins.

https://lupinepublishers.com/drug-designing-journal/abstracts/beyond-pain-fear-withdrawal-findings-and-problems-involving-change-treatment-and-application-for-a-chronic-addiction-on-alcohol-do-not-end.ID.000130.php

https://lupinepublishers.com/drug-designing-journal/fulltext/beyond-pain-fear-withdrawal-findings-and-problems-involving-change-treatment-and-application-for-a-chronic-addiction-on-alcohol-do-not-end.ID.000130.php

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journal of Drug Designing- Lupine Publishers

Depression in Pregnancy: Treat or Do Not Treat? by Amani Mohsen in DDIPIJ in Lupine Publishers

Globally, mental health disorders are increasingly prevalent worldwide with depression particularly contributed to the largest percentage of global disability (7.5% of all years lived with disability in 2015). It is more common in females than males affecting 4 -7% of women in reproductive age group [1]. Women with mild depression are treated with cognitive based therapy and antidepressants are used depending on the severity of the symptoms [2]. Utilizing antidepressants preconception and during pregnancy was assessed in wide range of studies to evaluate the risk of associated congenital anomalies. Ornoy et al reviewed the association between tricyclic antidepressants (TCA) and congenital anomalies. Early studies showed slight increase in the associated risk however the following large studies showed no association [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

https://lupinepublishers.com/drug-designing-journal/fulltext/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

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Journal of Drug Designing- Lupine Publishers

Extra-Marital Affair Can Lead Trauma and Connections in Higher Risk for Heart Disease in Indian Women by Rahul Hajare in DDIPIJ in Lupine Publishers

An Extra-marital affair relationship can break heart. Extramarital affair women, according to a study, have a higher risk for heart disease. Turns out, for women, being extra-marital affair can be injurious to health. According to a study conducted by the New York University, extra-marital affair women have a higher risk for heart disease compared with non-extra-marital affair women across several modifiable risk factors [1-3]. “Our findings highlight the impact of sexual orientation, specifically sexual identity, on the cardiovascular health of women and suggest clinicians and public health practitioners should develop tailored screening and prevention to reduce heart disease risk in extra-marital affair women,” Little is known about the impact of sexual orientation on heart disease risk in women, despite the fact that widow and extramarital affair women may be at a higher risk based on modifiable factors like tobacco use and poor mental health. In this study, the researchers examined differences in modifiable risk factors for heart disease and heart disease diagnoses in women of different sexual orientations. Risk factors measured included mental distress; health behaviours such as tobacco use, binge drinking, diet, and exercise; and biological risk factors such as obesity, hypertension, diabetes, and cholesterol [4].

https://lupinepublishers.com/drug-designing-journal/abstracts/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

https://lupinepublishers.com/drug-designing-journal/fulltext/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

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Semiconductor Quantum Dots as In-Vivo Imaging Agent:(DDIPIJ)- Lupine Publishers

Semiconductor Quantum Dots as In-Vivo Imaging Agent by Joydeep Dhar in DDIPIJ in Lupine Publishers

Inability to early diagnosis is a major concern for the treatment of fatal disease like cancer. Early diagnosis and treatment enhances the scope of disease curability. The accurate identification, realtime monitoring and targeting the cancerous tissues in a precise manner hold the key for longer progression free survival of a patient. Among different diagnostic techniques, fluorescence based minimally invasive bio-imaging techniques are considered to be ideal to have clear understanding about the physiological processes of the infected tissues as well as to reduce physical and mental stress of a patient. Super-resolution fluorescence microscopy has improved the spatial optical resolution of biological molecules, living cells and tissues with the use of highly fluorescent inorganic semiconductor nanocrystals, also known as quantum dots (QDs), with sizes ranging from 2 nm to 15 nm [1]. These nanocrystals comprised of elements belong to groups II–VI (eg, CdSe and CdTe), groups III–V (eg, InP), groups IV–VI (eg, PbS and PbSe) [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/semiconductor-quantum-dots-as-in-vivo-imaging-agent.ID.000124.php

https://lupinepublishers.com/drug-designing-journal/fulltext/semiconductor-quantum-dots-as-in-vivo-imaging-agent.ID.000124.php

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Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery:(DDIPIJ)- Lupine Publishers

Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery by Suresh Kumar in DDIPIJ in Lupine Publishers

Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as Parkinson disease, Alzheimer disease, diabetes, and so on. Recently IDPs are getting importance as desirable drug targets for major diseases. This review introduces IDP’s in drug discovery by experimental and by computational approach.

https://lupinepublishers.com/drug-designing-journal/abstracts/intrinsically-disordered-protein-idps-experimental-and-computational-approaches-in-drug-discovery.ID.000123.php

https://lupinepublishers.com/drug-designing-journal/fulltext/intrinsically-disordered-protein-idps-experimental-and-computational-approaches-in-drug-discovery.ID.000123.php

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Antioxidant Properties and Antibacterial Activities of Leptadenia hastata Leaves Extracts on Staphylococcus aureus: (DDIPIJ)- Lupine Publishers

Antioxidant Properties and Antibacterial Activities of Leptadenia hastata Leaves Extracts on Staphylococcus aureus by Isaac John Umaru in DDIPIJ in Lupine Publishers

Leptadenia hastata extracts were evaluated for antibacterial activity and antioxidant properties. The leaf of the plant was extracted with n-hexane, dichloromethane, ethyl acetate, chloroform and methanol to give respective extracts. The Antibacterial activity against Staphylococcus aureus, was determined by disc diffusion method. Antioxidant activity was assayed by the DPPH radical scavenging activity mechanism. The results showed that of n-hexane, ethyl acetate, dichloromethane, chloroform and methanol extracts of Leptadenia hastata, methanol extract and chloroform extracts displayed more activity with 1.10 ± 0.10ab and 0.97 ± 0.06ab than others at 25-1000ppm/desk of the extracts tested. The most antioxidant activities against DPPH were displayed by the hexane and methanol extracts of Leptadenia hastata leaf, exhibiting IC50 (63.44μg/mL) and IC50 (46.80μg/mL) respectively, followed by chloroform, dichloromethane and lastly ethyl acetate crude extract. The present results showed potential of the medicinal plant used by traditional herbal medical practitioners as natural anti-microbial, antioxidant and potentially antiinflammatory agents. The results confirm that Leptadenia hastata leaves extracts can be used as a source of drugs to fight infections caused by susceptible bacteria.

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