Chemical Study by GC-MS of the Essential Oils of Certain Mints Grown In the Region of Settat (Morocco): Mentha Piperita, Mentha Pulegium and Mentha Spicata: (DDIPIJ) - Lupine Publishers

Chemical Study by GC-MS of the Essential Oils of Certain Mints Grown In the Region of Settat (Morocco): Mentha Piperita, Mentha Pulegium and Mentha Spicata by Ayoub Ainane in DDIPIJ in Lupine Publishers

This work aims to evaluate the composition of the essential oils of certain mints grown in the region of Settat Morocco and to determine their chemical compositions. The essential oils obtained by hydrodistillation have an average yield of: 2.93% for Mentha pulegium, 1.23% for Mentha piperita and 0.91% for Mentha spicata. Analyzes of oils by GC-MS, showed the presence of several components including Menthone (42.97%) and Menthol (27.64%) are the major components of Mentha piperita, piperitone (31.27%) and piperitenone (22.98%) were obtained as the major compounds of Mentha pulegium, and so the main essential oil compounds of Mentha spicata are carvone (33.14%) and trans-Carveol (20.06%).

https://lupinepublishers.com/drug-designing-journal/abstracts/chemical-study-by-gc-ms-of-the-essential-oils-of-certain-mints-grown-in-the-region-of-settat-morocco-mentha-piperita-mentha-pulegium-and-mentha-spicata.ID.000120.php

https://lupinepublishers.com/drug-designing-journal/fulltext/chemical-study-by-gc-ms-of-the-essential-oils-of-certain-mints-grown-in-the-region-of-settat-morocco-mentha-piperita-mentha-pulegium-and-mentha-spicata.ID.000120.php

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Exercise Training And Molecular Markers: New Perspectives In The Rehabilitation Of COPD: (DDIPIJ) - Lupine Publishers

Exercise Training And Molecular Markers: New Perspectives In The Rehabilitation Of COPD by Calabrese Mariaconsiglia in DDIPIJ in Lupine Publishers

The present work is based on a careful analysis of the literature in order to find out what the right type of exercise can be recommended to the patient with COPD. Starting from the basic assumption that exercise is itself a biological therapy, we have looked to molecules that are critically altered in these patients so as to constitute potential molecular markers. We have also seen if, how, and how much the exercise is able to determine a modulation of the levels of these molecules in a functional sense to improve the clinical condition of the patients.

https://lupinepublishers.com/drug-designing-journal/abstracts/exercise-training-and-molecular-markers-new-perspectives-in-the-rehabilitation-of-copd.ID.000119.php

https://lupinepublishers.com/drug-designing-journal/fulltext/exercise-training-and-molecular-markers-new-perspectives-in-the-rehabilitation-of-copd.ID.000119.php

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Body on Chip-A Distant Dream or an Emerging Reality?: (DDIPIJ) - Lupine Publishers

Body on Chip-A Distant Dream or an Emerging Reality? by Ofra Benny in DDIPIJ in Lupine Publishers

We are currently facing a global health challenge regarding the way we discover and develop new drugs. Small biotech companies, as well as large pharmaceutical corporations, spend increasingly more money on the classical route of drug development, and it fails more often than it succeeds. Consequently, some diseases are not being treated and patients who are in dire need of new therapies are not receiving them.

https://lupinepublishers.com/drug-designing-journal/abstracts/body-on-chip-a-distant-dream-or-an-emerging-reality.ID.000118.php

https://lupinepublishers.com/drug-designing-journal/fulltext/body-on-chip-a-distant-dream-or-an-emerging-reality.ID.000118.php

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»N2B-Patch« – Nose-To-Brain Delivery of an Active Pharmaceutical Ingredient via the Olfactory Region: (DDIPIJ) - Lupine Publishers

»N2B-Patch« – Nose-To-Brain Delivery of an Active Pharmaceutical Ingredient via the Olfactory Region by Carmen Gruber Traub in DDIPIJ in Lupine Publishers

Within the EU funded project »N2B-patch« eleven partners from eight countries aim to develop an innovative technology for the nose-to-brain delivery of an active pharmaceutical ingredient via the olfactory region for the regenerative treatment of multiple sclerosis using novel multi-functional biomaterials combined with a medical device. The four year EU-funded research involves an innovative method of bypassing the blood-brain barrier by delivering a potential multiple sclerosis drug with a special medical device via the nose directly to the brain. 

https://lupinepublishers.com/drug-designing-journal/abstracts/n2b-patch-nose-to-brain-delivery-of-an-active-pharmaceutical-ingredient-via-the-olfactory-region.ID.000116.php

https://lupinepublishers.com/drug-designing-journal/fulltext/n2b-patch-nose-to-brain-delivery-of-an-active-pharmaceutical-ingredient-via-the-olfactory-region.ID.000116.php

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Regulation of Pharmacy Council of India and Assessment of Quality Life Among single Mother -By-Choice ‘Residing in slums Linkage Pharmaceutical Institutions in Pune, India: (DDIPIJ) - Lupine Publishers

Regulation of Pharmacy Council of India and Assessment of Quality Life Among single Mother -By-Choice ‘Residing in slums Linkage Pharmaceutical Institutions in Pune, India by Rahul Hajare in DDIPIJ in Lupine Publishers

Single mother cannot produce benefit properly which is required to children, playing, and other food source into energy. Researcher has been looking for simple and effective ways to deliver benefit into the children who have a single mother to child by their choices as well as single mother has to her choice. The most common one is taking orally that has financial support from organization which is privately manage and ruled out by under the surveillances of Pharmacy council of India. However research shows that is easily broken down by the system. This problem has solved by using intervention by secretarial level department of health research (DHR) government of India. These can be done by binding pharmacy council of India by department of health research with government of India. The encouragement is protected with monthly salary that has single mother by choice which is service privately manage under the influence pharmaceutical Institutions which is linkage of slums and rural area in India. Once financial support reaches the children’s, another pathway takes over to help financial pass into the children needs. Binding of regulatory of pharmacy council of India to single mother by choice residing in private pharmacy institution in slum makes the financial hitch a ride on this protected supply chain, where it is released to do its work. Financial help also causes stimulation of brain which leads to increased release of sertraline moieties. Finding simpler ways to deliver cause into the slums pharmacy institution is one important avenue for tackling the myth of single mother by choice that is sweeping the developing world and GDP in slum occupied pharmacy Institutions. Single mother by choice has specific mechanisms for protecting and absorbing valuable things that would usually be correlate by financial conditions and better delivery method to their children.

https://lupinepublishers.com/drug-designing-journal/abstracts/regulation-of-pharmacy-council-of-india-and-assessment-of-quality-life-among-single-mother.ID.000115.php

https://lupinepublishers.com/drug-designing-journal/fulltext/regulation-of-pharmacy-council-of-india-and-assessment-of-quality-life-among-single-mother.ID.000115.php

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Structural and Vibrational Study On the Acid, Hexa-Hydrated and Anhydrous Trisodic Salts of Antiviral Drug Foscarnet: (DDIPIJ)-Lupine Publishers

Structural and Vibrational Study On the Acid, Hexa-Hydrated and Anhydrous Trisodic Salts of Antiviral Drug Foscarnet by Silvia A Brandán in DDIPIJ in Lupine Publishers

The structural and vibrational properties of acid species, hexa-hydrated and anhydrous trisodic salts of antiviral drug foscarnet in gas phase and in aqueous solution have been studied in this work by using the hybrid B3LYP method with the 6-31G* and 6-311++G** basis sets. The properties in solution were carried out with the self consistent reaction force (SCRF) method by using the integral equation formalism variant polarised continuum (IEFPCM) and SD models while the complete vibrational assignments for those three species were performed in both media by using the experimental available infrared spectrum of hexa-hydrated trisodic salt and the scaled quantum mechanical force field (SQMFF) methodology. The natural bond orbital (NBO) studies suggest that the hexa-hydrated salt in solution is most stable than the anhydrous one in the same medium but in gas phases the anhydrous salt shows a higher stability in solution. The atoms in molecules (AIM) analyses have revealed the ionic characteristics of the O--- Na bonds in both salts supporting the higher stability of the hexa-hydrated salt in solution. The evaluation of the frontier orbitals show that the anhydrous salt is the most reactive species in solution, as supported by its higher solvation energy and volume variation. Apparently, the presences of phosphate group in foscarnet probably increase its activity when it is used as drug. The experimental infrared bands observed in the hexa-hydrated species at 1059 and 983 cm-1 are clearly attributed to the stretching modes of phosphate group while the strong bands at 1445 and 1333 cm-1 are associated to the stretching modes of carboxylate group. In addition, the force constants for the carboxylate and phosphate groups are reported.

https://www.lupinepublishers.com/drug-designing-journal/abstracts/structural-and-vibrational-study-on-the-acid-hexa-hydrated-and-anhydrous-trisodic-salts-of-antiviral-drug-foscarnet.ID.000114.php

https://www.lupinepublishers.com/drug-designing-journal/fulltext/structural-and-vibrational-study-on-the-acid-hexa-hydrated-and-anhydrous-trisodic-salts-of-antiviral-drug-foscarnet.ID.000114.php

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Gut Micro biome, Multiple Sclerosis, and Cancer:(DDIPIJ)-Lupine Publishers

Gut Micro biome, Multiple Sclerosis, and Cancer by Robert Skopec in DDIPIJ in Lupine Publishers

Thanks to their influence on the owner’s gut micro biome, dogs may be beneficial in reducing cardiovascular, diabetes, multiple sclerosis and cancer risk by providing a non-human form of social support and increasing physical activity. Ownership of hunting dog breeds was associated with a decreased risk of CVD, and ownership of all purebred breeds was associated with lower risk of all-cause mortality. Dog ownership has also been associated with elevated parasympathetic and diminished sympathetic nervous system activity, lower reactivity to stress, and faster recovery of blood pressure following stressful activity. We provide evidence that supports epsilon toxin’s ability to cause BBB permeability and show that epsilon toxin kills the brain’s myelin producing cells, oligodendrocytes; the same cells die in multiple sclerosis (MS) lesions. A new study has identified how the environment surrounding a tumor can stimulate metastatic behavior in the individual cancer cells. Researchers found that the tumor cells activate a particular set of genes and begin form blood vessel-like structure when they are confined in densely packed environment.

http://www.lupinepublishers.com/drug-designing-journal/abstracts/gut-micro-biome-multiple-sclerosis-and-cancer.ID.000113.php

http://www.lupinepublishers.com/drug-designing-journal/fulltext/gut-micro-biome-multiple-sclerosis-and-cancer.ID.000113.php

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A Comparison Study for Chances of Reduction in Cardiovascular Risk by Draksharishta in Induced Diabetic Condition:(DDIPIJ)-Lupine Publishers

A Comparison Study for Chances of Reduction in Cardiovascular Risk by Draksharishta in Induced Diabetic Condition by Subhajit Ghosh in DDIPIJ in Lupine Publishers

In this study was to evaluate the effect of Draksharishta-T and Draksharishta -M prepared by traditional and modern methods respectively and Dabur Draksharishta and comparison between them on fasting blood glucose and serum lipid profile in alloxan induced diabetic rats. Oral administration of Draksharishta-T, Draksharishta-M and Dabur Draksharishta (2ml/kg p.o.) for 21 days caused a significant decrease in fasting blood glucose (FBG) and showed significant rise in blood glutathione level (GSH) in diabetic rats. Glibenclamide was used as a standard anti diabetic drug (10 mg/kg, p.o). These preparations also caused significant reduction in serum cholesterol, LDL and triglycerides and showed significant rise in serum HDL level in diabetic albino rats. Thus all these preparations were able to maintain the tested parameters near to the normal level significantly.

http://www.lupinepublishers.com/drug-designing-journal/abstracts/a-comparison-study-for-chances-of-reduction-in-cardiovascular-risk-by-draksharishta-in-induced-diabetic-condition.ID.000111.php

http://www.lupinepublishers.com/drug-designing-journal/fulltext/a-comparison-study-for-chances-of-reduction-in-cardiovascular-risk-by-draksharishta-in-induced-diabetic-condition.ID.000111.php

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Regulatory Inflation in Pharmaceutical Drug Development?:(DDIPIJ)-Lupine Publishers

Regulatory Inflation in Pharmaceutical Drug Development? by François Xavier Lacasse in DDIPIJ in Lupine Publishers

During the last decade, and exponentially over the last three years, numerous pharmaceutical manufacturing plants have closed their doors following current Good Manufacturing Practices (cGMP) audits from various agencies, such as FDA, EMA and Health Canada. Regulatory affairs have been evolving and so should be the audits, auditors and regulations. However, the density and interpretations of regulatory requirements have become increasingly stringent, especially with respect to sterile products, making them more difficult to develop and manufacture within reasonable time and cost. A quick search on Google shows numerous press releases from various pharmaceutical organizations reporting critical/ major deficiencies, leading to temporary or permanent closures of manufacturing plants. Furthermore, it seems that this evolving situation has not only impacted drug shortage, but these events have placed the pharmaceutical industry under a permanent state of siege. The negative impacts of regulatory inflation are a center of attention among pharmaceutical professionals.

http://www.lupinepublishers.com/drug-designing-journal/abstracts/regulatory-inflation-in-pharmaceutical-drug-development.ID.000110.php

http://www.lupinepublishers.com/drug-designing-journal/fulltext/regulatory-inflation-in-pharmaceutical-drug-development.ID.000110.php

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