Preparation of Polyelectrolyte Hydrogels and Study Their Controlled Release of Gabapentin by Athir M Haddad in DDIPIJ in Lupine Publishers
The semi interpenetrating network hydrogels (Z1-Z15) were prepared from
different ratio of sodium alginate and linear poly
(acrylamide-co-diallyl dimethyl ammonium chloride) then they mixed with
the acrylamide and bisacrylamide as cross linking agent and polymerized
via redox polymerization to form the semi-IPNs. All prepared semi-IPNs
were loaded with three different amounts from Gabapentin as drug model.
The swelling characteristics were studied for all semi- IPN hydrogels by
determining the swelling ratio (Q).The release of Gabapentin was
followed by using U.V. spectroscopy at (202 , 201 and 204) nm at
constant temperature (37°C) in distilled water , simulated gastric fluid
(SGF) and simulated intestinal fluid (SIF) respectly. The results of
Gabapentin released indicated that all semi-IPNs have the ability to
release drug to environment and the amount of Gabapentin released about
50% during two hours. Higuchi equation was used to determine the Higuchi
constant which is very useful to forecasting the amount of Gabapentin
released theoretically.
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