Drug Designing & Intellectual Properties journals- Lupine Publishers

Beyond Pain, Fear, Withdrawal-Findings, And Problems Involving Change - Treatment and Application for A Chronic Addiction on Alcohol Do Not End by Loai Aljerf in DDIPIJ in Lupine Publishers

Alcohol use disorders (AUD) involving hazardous, harmful and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of the common inhibitors in the treatment of patients with AUD, taking into consideration, the short- and long- terms abstinence. An extensive literature search conducted in MEDLINE, PubMed, Scopus and CINAHL databases identified 776 articles, which were then evaluated for pre‐specified criteria for relevance and quality assurance. A total of 38 articles, including 36 human studies and 2 animal studies, were selected for this review. Many inhibitors used in the treatment of alcoholism and some were considered of effective medication when their intakes are supervised by an expert. However, their therapeutic efficacies vary widely; for instance, disulfiram is a pro-drug that requires its transformation into an active form and because it shows a wide range of secondary effects, it often prevents the use of doses that ensure full therapeutic effectiveness. Sex hormones play an important role in establishing sex‐distinctive brain structural and functional variations that could contribute to the sex differences in alcohol consumption behavior. Existing evidence supports the association of increased testosterone level and increased risk for alcohol use and AUD in males. In contrast, the evidence supports the association of increased estrogen level and increased alcohol use in females. Much less is known about the impact of progestins on alcohol use and misuse in human subjects. Future observational and experimental studies conducted in both sexes with a comprehensive hormone panel are needed to elucidate the impact of the interplay between various sex hormone levels during various developmental stages on alcohol userelated phenotypes and AUD. On the other hand, alcohol withdrawal-especially delirium tremens (DT)-is a potentially life-threatening condition. While short-term treatment regimens and factors that predispose to more severe symptomatology have been extensively studied, little attention has been paid to the clinical epidemiology and long-term care of the chronic medical, addictive, psychiatric, and psychosocial problems faced by these patients. Chronic alcoholic patients are frequently suffering from specific micronutrient deficiencies, including vitamins involved in one carbon metabolism. The deficiencies commonly involve folate, vitamin B6, thiamine, and vitamin A. Inadequate dietary intake is a major cause of the vitamin deficiency. As a consequence of chronic alcohol intake, could lead to metabolic disruption and potentially to hyperhomocysteinemia. Alcoholism can affect the absorption, storage, metabolism, and activation of many of these vitamins.

https://lupinepublishers.com/drug-designing-journal/abstracts/beyond-pain-fear-withdrawal-findings-and-problems-involving-change-treatment-and-application-for-a-chronic-addiction-on-alcohol-do-not-end.ID.000130.php

https://lupinepublishers.com/drug-designing-journal/fulltext/beyond-pain-fear-withdrawal-findings-and-problems-involving-change-treatment-and-application-for-a-chronic-addiction-on-alcohol-do-not-end.ID.000130.php

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Journal of Drug Design and Development-Lupine Publishers

Secret Sonic Weapons’ War Lead to Carcinogenesis by Robert Skopec  in DDIPIJ in Lupine Publishers 

State Department evacuates a number of Americans from the US consulate in Guangzhou, China after they experienced unexplained health issues. A group of US diplomats stationed in China have been brought back to the states after being inflicted by a mystery illness that reportedly resembles the brain injuries previously suffered by staff in Cuba. Heather Nauert, a State Department spokeswoman, said in a statement that the individuals from the US office in Guangzhou were returned home for further evaluation. It was unclear if there was any connection to last year’s situation in Cuba where 24 US government employees experienced a range of ailments after hearing an unusual sound.

https://lupinepublishers.com/drug-designing-journal/abstracts/secret-sonic-weapons-war-lead-to-carcinogenesis.ID.000129.php

https://lupinepublishers.com/drug-designing-journal/fulltext/secret-sonic-weapons-war-lead-to-carcinogenesis.ID.000129.php

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journal of Drug Designing- Lupine Publishers

Depression in Pregnancy: Treat or Do Not Treat? by Amani Mohsen in DDIPIJ in Lupine Publishers

Globally, mental health disorders are increasingly prevalent worldwide with depression particularly contributed to the largest percentage of global disability (7.5% of all years lived with disability in 2015). It is more common in females than males affecting 4 -7% of women in reproductive age group [1]. Women with mild depression are treated with cognitive based therapy and antidepressants are used depending on the severity of the symptoms [2]. Utilizing antidepressants preconception and during pregnancy was assessed in wide range of studies to evaluate the risk of associated congenital anomalies. Ornoy et al reviewed the association between tricyclic antidepressants (TCA) and congenital anomalies. Early studies showed slight increase in the associated risk however the following large studies showed no association [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

https://lupinepublishers.com/drug-designing-journal/fulltext/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

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Journal of Drug Designing- Lupine Publishers

Extra-Marital Affair Can Lead Trauma and Connections in Higher Risk for Heart Disease in Indian Women by Rahul Hajare in DDIPIJ in Lupine Publishers

An Extra-marital affair relationship can break heart. Extramarital affair women, according to a study, have a higher risk for heart disease. Turns out, for women, being extra-marital affair can be injurious to health. According to a study conducted by the New York University, extra-marital affair women have a higher risk for heart disease compared with non-extra-marital affair women across several modifiable risk factors [1-3]. “Our findings highlight the impact of sexual orientation, specifically sexual identity, on the cardiovascular health of women and suggest clinicians and public health practitioners should develop tailored screening and prevention to reduce heart disease risk in extra-marital affair women,” Little is known about the impact of sexual orientation on heart disease risk in women, despite the fact that widow and extramarital affair women may be at a higher risk based on modifiable factors like tobacco use and poor mental health. In this study, the researchers examined differences in modifiable risk factors for heart disease and heart disease diagnoses in women of different sexual orientations. Risk factors measured included mental distress; health behaviours such as tobacco use, binge drinking, diet, and exercise; and biological risk factors such as obesity, hypertension, diabetes, and cholesterol [4].

https://lupinepublishers.com/drug-designing-journal/abstracts/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

https://lupinepublishers.com/drug-designing-journal/fulltext/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

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An Overview on Niosomes: A Drug Nanocarrier:(DDIPIJ)- Lupine Publishers

An Overview on Niosomes: A Drug Nanocarrier by Dina Louis in DDIPIJ in Lupine Publishers

Niosome are non-ionic surfactant vesicles acquired on hydration of synthetic nonionic surfactants, with or without consolidation of cholesterol or their lipids. They are vesicular systems like liposome’s that can be utilized as transporters of amphiphilic and lipophilic medications. Niosomes are promising vehicle for drug delivery and being non-ionic; and Niosomes are biodegradable, biocompatible non immunogenic and show adaptability and flexibility in their structural characterization. Niosomes have been generally assessed for controlled discharge and targeted delivery for the treatment of tumor, viral infections and other microbial illnesses. Niosomes can entangle both hydrophilic and lipophilic medications and can prolong the circulation of the entrapped medication in body. Encapsulation of medication in vesicular system can be anticipated to delay the presence of medication in the systemic circulation and enhance penetration into target tissue, maybe decrease toxicity if specific take-up can be accomplished. This review focuses on components of niosomes, types, the advantages, preparation methods, factors affecting, characterizations, and applications of noisome.

https://lupinepublishers.com/drug-designing-journal/abstracts/an-overview-on-niosomes-a-drug-nanocarrier.ID.000125.php

https://lupinepublishers.com/drug-designing-journal/fulltext/an-overview-on-niosomes-a-drug-nanocarrier.ID.000125.php

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Semiconductor Quantum Dots as In-Vivo Imaging Agent:(DDIPIJ)- Lupine Publishers

Semiconductor Quantum Dots as In-Vivo Imaging Agent by Joydeep Dhar in DDIPIJ in Lupine Publishers

Inability to early diagnosis is a major concern for the treatment of fatal disease like cancer. Early diagnosis and treatment enhances the scope of disease curability. The accurate identification, realtime monitoring and targeting the cancerous tissues in a precise manner hold the key for longer progression free survival of a patient. Among different diagnostic techniques, fluorescence based minimally invasive bio-imaging techniques are considered to be ideal to have clear understanding about the physiological processes of the infected tissues as well as to reduce physical and mental stress of a patient. Super-resolution fluorescence microscopy has improved the spatial optical resolution of biological molecules, living cells and tissues with the use of highly fluorescent inorganic semiconductor nanocrystals, also known as quantum dots (QDs), with sizes ranging from 2 nm to 15 nm [1]. These nanocrystals comprised of elements belong to groups II–VI (eg, CdSe and CdTe), groups III–V (eg, InP), groups IV–VI (eg, PbS and PbSe) [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/semiconductor-quantum-dots-as-in-vivo-imaging-agent.ID.000124.php

https://lupinepublishers.com/drug-designing-journal/fulltext/semiconductor-quantum-dots-as-in-vivo-imaging-agent.ID.000124.php

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Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery:(DDIPIJ)- Lupine Publishers

Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery by Suresh Kumar in DDIPIJ in Lupine Publishers

Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as Parkinson disease, Alzheimer disease, diabetes, and so on. Recently IDPs are getting importance as desirable drug targets for major diseases. This review introduces IDP’s in drug discovery by experimental and by computational approach.

https://lupinepublishers.com/drug-designing-journal/abstracts/intrinsically-disordered-protein-idps-experimental-and-computational-approaches-in-drug-discovery.ID.000123.php

https://lupinepublishers.com/drug-designing-journal/fulltext/intrinsically-disordered-protein-idps-experimental-and-computational-approaches-in-drug-discovery.ID.000123.php

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