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Intellectual Property Journal- Lupine Publishers

Successively Substituting an Additional 4-(2-Aminoethyl) Aniline Group in Fabricated Isoindoline-1,3-Dione Scaffold Enhances the Antimicrobial Potency: Part II of Research by Debarshi Kar Mahapatra in DDIPIJ in Lupine Publishers

The irrational use of antimicrobial agents for several decades has led to the drug-resistance among the patient population. Overcoming the present drug-resistance is a major challenge for modern day scientists. In order to counter this problem, several approaches have been utilized, one of which involve drug design and discovery, where new classes or unexplored chemical moieties are explored for a particular activity, either serendipitously or quite rationally. Learning lessons from the previously synthesized four compounds (Part-I of Research), we have now (Part-II of Research) designed two compounds (3 and 5) by incorporating an additional 4-(2-aminoethyl)aniline group in the fabricated isoindoline-1,3-dione scaffold by successive synthetic step utilizing similar protocol and screened them against the above four mentioned pathogenic microbes in a similar way. The present exploration is an attempt to rationally overcome the microbial drug resistance by the efficacious and potent nature of the compounds. Compound (5) exhibited the highest activity against A. niger with ZOI diameter of >29mm. All the compounds showed more or less nearly the same activity. From this study, it may be concluded that substituting the amine/amide-based components leads to an increase in the potency of the compared along with better-anti-fungal activity. Therefore, the current exploration helped to design the compounds which have better potency than our previous reports and also providing imperative knowledge regarding the selection of the substituents. The encouraging results will further motivate us in developing novel and better inhibitors of phthalimide scaffold in the future.

https://lupinepublishers.com/drug-designing-journal/abstracts/successively-substituting-an-additional-4-2-aminoethyl-aniline-group-in-fabricated.ID.000132.php
https://lupinepublishers.com/drug-designing-journal/fulltext/successively-substituting-an-additional-4-2-aminoethyl-aniline-group-in-fabricated.ID.000132.php

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journal of Drug Designing- Lupine Publishers

Cytotoxicity and Antioxidant Potentials of Barringtonia Asiatica Essential Oil by Isaac John Umaru in DDIPIJ in Lupine Publishers

Essential oils are liquid mixture of volatile compound obtained from aromatic plants. It was observed that many essential oils have antioxidant properties and can present antimicrobial activities. The Aim of the present study were:
a) to determine the cytotoxicity lethality of the leafs and stem-bark of Barringtonia asiatica using brine shrimp (Artimia salina).

b) to evaluate the antioxidant potential of composition of the leaf and stem-bark essential oil using the DPPH (2,2-diphenyl-1- picrylhydrazyl) free radical scavenging assay. The essential oil exhibited a mild toxicity and significant IC50 of 36.55μg/mL and 22.10μg/mL value of antioxidant potential leaf and stem-bark of Barringtonia asiatica respectively.

https://lupinepublishers.com/drug-designing-journal/abstracts/cytotoxicity-and-antioxidant-potentials-of-barringtonia-asiatica-essential-oil.ID.000131.php
https://lupinepublishers.com/drug-designing-journal/fulltext/cytotoxicity-and-antioxidant-potentials-of-barringtonia-asiatica-essential-oil.ID.000131.php

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Drug Designing & Intellectual Properties journals- Lupine Publishers

Beyond Pain, Fear, Withdrawal-Findings, And Problems Involving Change - Treatment and Application for A Chronic Addiction on Alcohol Do Not End by Loai Aljerf in DDIPIJ in Lupine Publishers

Alcohol use disorders (AUD) involving hazardous, harmful and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of the common inhibitors in the treatment of patients with AUD, taking into consideration, the short- and long- terms abstinence. An extensive literature search conducted in MEDLINE, PubMed, Scopus and CINAHL databases identified 776 articles, which were then evaluated for pre‐specified criteria for relevance and quality assurance. A total of 38 articles, including 36 human studies and 2 animal studies, were selected for this review. Many inhibitors used in the treatment of alcoholism and some were considered of effective medication when their intakes are supervised by an expert. However, their therapeutic efficacies vary widely; for instance, disulfiram is a pro-drug that requires its transformation into an active form and because it shows a wide range of secondary effects, it often prevents the use of doses that ensure full therapeutic effectiveness. Sex hormones play an important role in establishing sex‐distinctive brain structural and functional variations that could contribute to the sex differences in alcohol consumption behavior. Existing evidence supports the association of increased testosterone level and increased risk for alcohol use and AUD in males. In contrast, the evidence supports the association of increased estrogen level and increased alcohol use in females. Much less is known about the impact of progestins on alcohol use and misuse in human subjects. Future observational and experimental studies conducted in both sexes with a comprehensive hormone panel are needed to elucidate the impact of the interplay between various sex hormone levels during various developmental stages on alcohol userelated phenotypes and AUD. On the other hand, alcohol withdrawal-especially delirium tremens (DT)-is a potentially life-threatening condition. While short-term treatment regimens and factors that predispose to more severe symptomatology have been extensively studied, little attention has been paid to the clinical epidemiology and long-term care of the chronic medical, addictive, psychiatric, and psychosocial problems faced by these patients. Chronic alcoholic patients are frequently suffering from specific micronutrient deficiencies, including vitamins involved in one carbon metabolism. The deficiencies commonly involve folate, vitamin B6, thiamine, and vitamin A. Inadequate dietary intake is a major cause of the vitamin deficiency. As a consequence of chronic alcohol intake, could lead to metabolic disruption and potentially to hyperhomocysteinemia. Alcoholism can affect the absorption, storage, metabolism, and activation of many of these vitamins.

https://lupinepublishers.com/drug-designing-journal/abstracts/beyond-pain-fear-withdrawal-findings-and-problems-involving-change-treatment-and-application-for-a-chronic-addiction-on-alcohol-do-not-end.ID.000130.php

https://lupinepublishers.com/drug-designing-journal/fulltext/beyond-pain-fear-withdrawal-findings-and-problems-involving-change-treatment-and-application-for-a-chronic-addiction-on-alcohol-do-not-end.ID.000130.php

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Journal of Drug Design and Development-Lupine Publishers

Secret Sonic Weapons’ War Lead to Carcinogenesis by Robert Skopec  in DDIPIJ in Lupine Publishers 

State Department evacuates a number of Americans from the US consulate in Guangzhou, China after they experienced unexplained health issues. A group of US diplomats stationed in China have been brought back to the states after being inflicted by a mystery illness that reportedly resembles the brain injuries previously suffered by staff in Cuba. Heather Nauert, a State Department spokeswoman, said in a statement that the individuals from the US office in Guangzhou were returned home for further evaluation. It was unclear if there was any connection to last year’s situation in Cuba where 24 US government employees experienced a range of ailments after hearing an unusual sound.

https://lupinepublishers.com/drug-designing-journal/abstracts/secret-sonic-weapons-war-lead-to-carcinogenesis.ID.000129.php

https://lupinepublishers.com/drug-designing-journal/fulltext/secret-sonic-weapons-war-lead-to-carcinogenesis.ID.000129.php

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journal of Drug Designing- Lupine Publishers

Depression in Pregnancy: Treat or Do Not Treat? by Amani Mohsen in DDIPIJ in Lupine Publishers

Globally, mental health disorders are increasingly prevalent worldwide with depression particularly contributed to the largest percentage of global disability (7.5% of all years lived with disability in 2015). It is more common in females than males affecting 4 -7% of women in reproductive age group [1]. Women with mild depression are treated with cognitive based therapy and antidepressants are used depending on the severity of the symptoms [2]. Utilizing antidepressants preconception and during pregnancy was assessed in wide range of studies to evaluate the risk of associated congenital anomalies. Ornoy et al reviewed the association between tricyclic antidepressants (TCA) and congenital anomalies. Early studies showed slight increase in the associated risk however the following large studies showed no association [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

https://lupinepublishers.com/drug-designing-journal/fulltext/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

For more Lupine Publishers Open Access Journals Please visit our website: http://www.lupinepublishers.com/

For more journal of Drug Designing articles Please Click Here: https://lupinepublishers.com/drug-designing-journal/

Journal of Drug Designing- Lupine Publishers

Extra-Marital Affair Can Lead Trauma and Connections in Higher Risk for Heart Disease in Indian Women by Rahul Hajare in DDIPIJ in Lupine Publishers

An Extra-marital affair relationship can break heart. Extramarital affair women, according to a study, have a higher risk for heart disease. Turns out, for women, being extra-marital affair can be injurious to health. According to a study conducted by the New York University, extra-marital affair women have a higher risk for heart disease compared with non-extra-marital affair women across several modifiable risk factors [1-3]. “Our findings highlight the impact of sexual orientation, specifically sexual identity, on the cardiovascular health of women and suggest clinicians and public health practitioners should develop tailored screening and prevention to reduce heart disease risk in extra-marital affair women,” Little is known about the impact of sexual orientation on heart disease risk in women, despite the fact that widow and extramarital affair women may be at a higher risk based on modifiable factors like tobacco use and poor mental health. In this study, the researchers examined differences in modifiable risk factors for heart disease and heart disease diagnoses in women of different sexual orientations. Risk factors measured included mental distress; health behaviours such as tobacco use, binge drinking, diet, and exercise; and biological risk factors such as obesity, hypertension, diabetes, and cholesterol [4].

https://lupinepublishers.com/drug-designing-journal/abstracts/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

https://lupinepublishers.com/drug-designing-journal/fulltext/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

For more Lupine Publishers Open Access Journals Please visit our website: http://www.lupinepublishers.com/

For more journal of Drug Designing articles Please Click Here: https://lupinepublishers.com/drug-designing-journal/index.php