journal of Drug Designing- Lupine Publishers

Depression in Pregnancy: Treat or Do Not Treat? by Amani Mohsen in DDIPIJ in Lupine Publishers

Globally, mental health disorders are increasingly prevalent worldwide with depression particularly contributed to the largest percentage of global disability (7.5% of all years lived with disability in 2015). It is more common in females than males affecting 4 -7% of women in reproductive age group [1]. Women with mild depression are treated with cognitive based therapy and antidepressants are used depending on the severity of the symptoms [2]. Utilizing antidepressants preconception and during pregnancy was assessed in wide range of studies to evaluate the risk of associated congenital anomalies. Ornoy et al reviewed the association between tricyclic antidepressants (TCA) and congenital anomalies. Early studies showed slight increase in the associated risk however the following large studies showed no association [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

https://lupinepublishers.com/drug-designing-journal/fulltext/depression-in-pregnancy-treat-or-do-not-treat.ID.000128.php

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Journal of Drug Designing- Lupine Publishers

Extra-Marital Affair Can Lead Trauma and Connections in Higher Risk for Heart Disease in Indian Women by Rahul Hajare in DDIPIJ in Lupine Publishers

An Extra-marital affair relationship can break heart. Extramarital affair women, according to a study, have a higher risk for heart disease. Turns out, for women, being extra-marital affair can be injurious to health. According to a study conducted by the New York University, extra-marital affair women have a higher risk for heart disease compared with non-extra-marital affair women across several modifiable risk factors [1-3]. “Our findings highlight the impact of sexual orientation, specifically sexual identity, on the cardiovascular health of women and suggest clinicians and public health practitioners should develop tailored screening and prevention to reduce heart disease risk in extra-marital affair women,” Little is known about the impact of sexual orientation on heart disease risk in women, despite the fact that widow and extramarital affair women may be at a higher risk based on modifiable factors like tobacco use and poor mental health. In this study, the researchers examined differences in modifiable risk factors for heart disease and heart disease diagnoses in women of different sexual orientations. Risk factors measured included mental distress; health behaviours such as tobacco use, binge drinking, diet, and exercise; and biological risk factors such as obesity, hypertension, diabetes, and cholesterol [4].

https://lupinepublishers.com/drug-designing-journal/abstracts/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

https://lupinepublishers.com/drug-designing-journal/fulltext/extra-marital-affair-can-lead-trauma-and-connections-in-higher-risk-for-heart-disease-in-indian-women.ID.000126.php

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An Overview on Niosomes: A Drug Nanocarrier:(DDIPIJ)- Lupine Publishers

An Overview on Niosomes: A Drug Nanocarrier by Dina Louis in DDIPIJ in Lupine Publishers

Niosome are non-ionic surfactant vesicles acquired on hydration of synthetic nonionic surfactants, with or without consolidation of cholesterol or their lipids. They are vesicular systems like liposome’s that can be utilized as transporters of amphiphilic and lipophilic medications. Niosomes are promising vehicle for drug delivery and being non-ionic; and Niosomes are biodegradable, biocompatible non immunogenic and show adaptability and flexibility in their structural characterization. Niosomes have been generally assessed for controlled discharge and targeted delivery for the treatment of tumor, viral infections and other microbial illnesses. Niosomes can entangle both hydrophilic and lipophilic medications and can prolong the circulation of the entrapped medication in body. Encapsulation of medication in vesicular system can be anticipated to delay the presence of medication in the systemic circulation and enhance penetration into target tissue, maybe decrease toxicity if specific take-up can be accomplished. This review focuses on components of niosomes, types, the advantages, preparation methods, factors affecting, characterizations, and applications of noisome.

https://lupinepublishers.com/drug-designing-journal/abstracts/an-overview-on-niosomes-a-drug-nanocarrier.ID.000125.php

https://lupinepublishers.com/drug-designing-journal/fulltext/an-overview-on-niosomes-a-drug-nanocarrier.ID.000125.php

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Semiconductor Quantum Dots as In-Vivo Imaging Agent:(DDIPIJ)- Lupine Publishers

Semiconductor Quantum Dots as In-Vivo Imaging Agent by Joydeep Dhar in DDIPIJ in Lupine Publishers

Inability to early diagnosis is a major concern for the treatment of fatal disease like cancer. Early diagnosis and treatment enhances the scope of disease curability. The accurate identification, realtime monitoring and targeting the cancerous tissues in a precise manner hold the key for longer progression free survival of a patient. Among different diagnostic techniques, fluorescence based minimally invasive bio-imaging techniques are considered to be ideal to have clear understanding about the physiological processes of the infected tissues as well as to reduce physical and mental stress of a patient. Super-resolution fluorescence microscopy has improved the spatial optical resolution of biological molecules, living cells and tissues with the use of highly fluorescent inorganic semiconductor nanocrystals, also known as quantum dots (QDs), with sizes ranging from 2 nm to 15 nm [1]. These nanocrystals comprised of elements belong to groups II–VI (eg, CdSe and CdTe), groups III–V (eg, InP), groups IV–VI (eg, PbS and PbSe) [2].

https://lupinepublishers.com/drug-designing-journal/abstracts/semiconductor-quantum-dots-as-in-vivo-imaging-agent.ID.000124.php

https://lupinepublishers.com/drug-designing-journal/fulltext/semiconductor-quantum-dots-as-in-vivo-imaging-agent.ID.000124.php

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Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery:(DDIPIJ)- Lupine Publishers

Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery by Suresh Kumar in DDIPIJ in Lupine Publishers

Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as Parkinson disease, Alzheimer disease, diabetes, and so on. Recently IDPs are getting importance as desirable drug targets for major diseases. This review introduces IDP’s in drug discovery by experimental and by computational approach.

https://lupinepublishers.com/drug-designing-journal/abstracts/intrinsically-disordered-protein-idps-experimental-and-computational-approaches-in-drug-discovery.ID.000123.php

https://lupinepublishers.com/drug-designing-journal/fulltext/intrinsically-disordered-protein-idps-experimental-and-computational-approaches-in-drug-discovery.ID.000123.php

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Antioxidant Properties and Antibacterial Activities of Leptadenia hastata Leaves Extracts on Staphylococcus aureus: (DDIPIJ)- Lupine Publishers

Antioxidant Properties and Antibacterial Activities of Leptadenia hastata Leaves Extracts on Staphylococcus aureus by Isaac John Umaru in DDIPIJ in Lupine Publishers

Leptadenia hastata extracts were evaluated for antibacterial activity and antioxidant properties. The leaf of the plant was extracted with n-hexane, dichloromethane, ethyl acetate, chloroform and methanol to give respective extracts. The Antibacterial activity against Staphylococcus aureus, was determined by disc diffusion method. Antioxidant activity was assayed by the DPPH radical scavenging activity mechanism. The results showed that of n-hexane, ethyl acetate, dichloromethane, chloroform and methanol extracts of Leptadenia hastata, methanol extract and chloroform extracts displayed more activity with 1.10 ± 0.10ab and 0.97 ± 0.06ab than others at 25-1000ppm/desk of the extracts tested. The most antioxidant activities against DPPH were displayed by the hexane and methanol extracts of Leptadenia hastata leaf, exhibiting IC50 (63.44μg/mL) and IC50 (46.80μg/mL) respectively, followed by chloroform, dichloromethane and lastly ethyl acetate crude extract. The present results showed potential of the medicinal plant used by traditional herbal medical practitioners as natural anti-microbial, antioxidant and potentially antiinflammatory agents. The results confirm that Leptadenia hastata leaves extracts can be used as a source of drugs to fight infections caused by susceptible bacteria.

https://lupinepublishers.com/drug-designing-journal/abstracts/antioxidant-properties-and-antibacterial-activities-of-leptadenia-hastata-leaves-extracts-on-staphylococcus-aureus.ID.000122.php

https://lupinepublishers.com/drug-designing-journal/fulltext/antioxidant-properties-and-antibacterial-activities-of-leptadenia-hastata-leaves-extracts-on-staphylococcus-aureus.ID.000122.php

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Preparatory Preparations for the Study of Drug Therapies for Emergency Diseases:(DDIPIJ)- Lupine Publishers

Preparatory Preparations for the Study of Drug Therapies for Emergency Diseases by Chang Rok Jeong in DDIPIJ in Lupine Publishers

In the US, more than 400,000 medical treatments are carried out each year to eliminate intestinal adhesion. The economic loss from these medical treatments is estimated to be about $1.2 billion. This economic loss has been significant, and the search results from pub med under keyword Intestinal Obstruction have been decreasing since 2015. It is difficult to research and prevent a disease caused by small intestine, which is one of the emergency diseases. Because emergency diseases have structural problems that are very difficult to collect and analyze data for research. Emergency care measures, especially drug development, require a platform that allows public funding and sharing of clinical data. Emergency diseases have scattered clinical data. The research into this emergency disease requires a method of receiving clinical data as a condition to provide free medical treatment to patients through the IRB. There is an urgent need to find the reverse data. Modern society is a time of the Fourth Industrial Revolution. Above all, AI, Deep Learning, and platforms are important keywords. In these times, open and international cooperation is necessary for the safety of emergency patients such as intestinal obstruction. Development guidelines describe how medicine will overcome these shortcomings during the Fourth Industrial Revolution.

https://lupinepublishers.com/drug-designing-journal/abstracts/preparatory-preparations-for-the-study-of-drug-therapies-for-emergency-diseases.ID.000121.php

https://lupinepublishers.com/drug-designing-journal/fulltext/preparatory-preparations-for-the-study-of-drug-therapies-for-emergency-diseases.ID.000121.php

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